I want my workflow to consider only weekdays while checking conditions. Is this possible?

Yes, it is possible. If you want to consider only weekdays, you can use the following workflow conditions:

• Less than weekdays ago
• Less than weekdays later
• More than weekdays ago
• More than weekdays later
• Weekdays ago
• Weekdays later

For example, to send an email to a contact three weekdays before the deal’s close date, you must set up the condition under Entry Criteria as 'Expected Close Date - Week Days Later - 3'.
In this case, workflows exclude non-working days based on what is specified in the business hours.
To learn more about workflow conditions, click here.